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反應結晶是指氣體與液體或液體與液體之間進行化學反應產(chǎn)生難溶或不溶固相物質(zhì)的過程。反應結晶法可以使一些易生成沉淀的物質(zhì)與其它化合物分離，從而達到純化的目的。
反應結晶過程有高選擇性的特點，常用于產(chǎn)品的分離提純。
Reaction crystallization refers to the chemical reaction between a gas and a liquid or liquid or liquid to produce insoluble or insoluble solid matter. Reactive crystallization can make some easily precipitated substances separate from other compounds, so as to achieve the purpose of purification. The reaction crystallization process is characterized by high selectivity and is often used in the separation and purification of products.
反應結晶的幾個影響因素：飽和度，溫度，混合均勻度，攪拌強度，物質(zhì)純度。
普通結晶罐自動化程度低，兩相或多相物料混合，為了達到好的混合效果，攪拌強烈，容易產(chǎn)生大量細晶，當細晶小于1μm 時，細晶會有團聚現(xiàn)象，即范得華力會起作用。因此產(chǎn)品粒度分布過寬，粘度變大，洗滌量增加，離心后晶間包裹的殘液量相對增大，導致產(chǎn)品純度低，另外操作靠經(jīng)驗和簡單的指標控制，不同班次工人操作有差異?？寇囬g管理難解決問題，導致產(chǎn)品批間差異大，粒度分布不均勻，產(chǎn)品質(zhì)量不穩(wěn)定；從綜合成本考慮，間歇操作繁瑣，動力消耗高，不適合批量產(chǎn)品的生產(chǎn)。
Several factors affecting reactive crystallization: degree of saturation, temperature, mixing uniformity, agitation strength, and material purity. The ordinary crystallization tank is low in automation, and when the two phase or multiphase materials are mixed, In order to achieve good mixing effect, the stirring process can be strong and easily producing a lot of fine grains. When the fine grain is less than 1 m, the fine grain will reunion, the Van der Waals force will come into effect. Therefore, when the product size distribution is too wide, the viscosity becomes larger, the washing capacity increases, and the residual liquid content between the crystals increases relatively after centrifugation, the low purity of the product will be caused. In addition, the operation is controlled by experience and simple indicators, and there are differences in the operation of workers in different shifts. The difficulty to solve problems by workshop management results in large differences among the products, uneven distribution of grain size, and unstable quality of products. Considering the comprehensive cost, the intermittent operation is tedious, the power consumption is high, and it is not suitable for the production of mass products.
反應結晶設備完全解決了上述問題，產(chǎn)品質(zhì)量達到了國外科學標準。反應結晶過程是一個復雜的傳熱、傳質(zhì)過程。在不同的物理、化學環(huán)境中，結晶過程的控制步驟可能改變，反映不同的行為。特別是藥物結晶產(chǎn)品，對產(chǎn)品晶型有嚴格要求，對產(chǎn)品的粒度分布的也有要求，它直接影響著藥物的品質(zhì)。
The reaction crystallization equipment can completely solve the above problems, and the product quality has reached the foreign advanced standards. The reaction crystallization is a complex process of heat and mass transfer. In different physical and chemical environments, the control steps of the crystallization process may change and reflect different behaviors. Especially for the pharmaceutical crystallization products. They have strict requirements on the crystal type, and also on the particle size distribution of the products, which directly affects the quality of drugs.
ND反應結晶器：設備內(nèi)部溫度，溶液pH值、容易控制。反應結晶器結構簡單、能耗低，而且結晶粒度分布均勻，可按要求生產(chǎn)純度較高的大晶，晶粒均勻易于過濾，對產(chǎn)品的質(zhì)量是一個大的提高。
ND Crystallizer: easy to control the internal temperature, pH value of solution; simple structure, low energy consumption, uniform distribution of crystals; can produce high-purity large crystal grains based on indications; easy to filter; a great improvement to product quality.
ND反應結晶器內(nèi)壁和導流筒部分拋光以減少結壁現(xiàn)象
The inner wall and draft tubes of ND Crystallizers are polished to reduce wall scars.
1、可配晶體消除裝置；上部微細晶體進細晶消除器后變?yōu)檫^飽和溶液回結晶器繼續(xù)結晶。
equipped with crystal elimination device; The upper micro crystal enters the fine crystal eliminator and then becomes supersaturated solution, continues to crystallize.
2、結晶器下部裝淘洗腿，有利于比重大的晶體采出。
The lower part of the crystallizer is provided with a panning leg, which is beneficial to the extraction of the larger crystals.
3、如果需要，可以設置晶種加入器，加入晶種進一步改善產(chǎn)品粒度分布。
If necessary, the crystal seed feeder can be added to further improve the particle size distribution
4、結晶器可以調(diào)整反應結晶溫度，參照好的反應速率來設定。
we can adjust the reaction crystallization temperature according to the optimum reaction rate
5、結晶機工作電壓：380V；設備工作時間：24h/d；
Operating voltage: 380V; working time: 24h/d
6、自控部分：根據(jù)自控部分的設計要求，系統(tǒng)可實現(xiàn)以下目標：
Automatic control part: according to the design requirements of the automatic control part, the system can achieve the following goals:
（1）各控制器的技術參數(shù)，保證工藝上的要求，能夠自動監(jiān)測控制結晶溫度等指標，泵采用變頻控制，進、出料作業(yè)能夠自動控制；
The technical parameters of each controller ensure the requirements of the process, and can automatically monitor and control the crystal temperature and other indicators. The pump adopts frequency conversion control, and the feed and discharge operations can be automatically controlled;
（2）現(xiàn)場執(zhí)行機構有系統(tǒng)信息上傳接口，可接入DCS系統(tǒng)。
The field executing organization has the system information uploading interface, and can access the DCS system.